The lecturer at Faculty of Medicine Dr. Samer Makki Mohamed Al-Hakkak publishes a research titled "" Bilateral Inguinal Lymphadenopathy as Initial Manifestation of Sarcoidosis " in the Indian journal "Journal of Case Reports&quo
Bilateral Inguinal Lymphadenopathy as Initial Manifestation of Sarcoidosis
Samer Makki Mohamed Al-Hakkak
Department of Surgery, Faculty of Medicine, Jabir Ibn Hayyan Medical University, Najaf City, Iraq.
Dr. Samer Makki Mohamed Al-Hakkak
Background: Sarcoidosis is a systemic granulomatous disorder of unknown cause characterized by frequent pulmonary involvement. Despite pulmonary involvement in most patients, sarcoidosis can have varied presentations. The clinical presentation of sarcoidosis is highly variable. Lymph node involvement is rarely found in isolation. Case Report: A 57-year-old asymptomatic male presented with bilateral pelvic and inguinal lymphadenopathy. A computed tomography (CT) scan of the chest, abdomen, and pelvis revealed bilateral deep pelvic and inguinal bulky adenopathy. Excision biopsy revealed sarcoidosis. He responded to six months of oral steroid treatment. Follow-up computed tomography scan after 6 months of steroid therapy showed complete resolution. Conclusion: This case exemplifies the difficulty in diagnosing sarcoidosis in its initial stages. A high index of suspicion and excision biopsy is the key in diagnosing this condition.
Sarcoidosis is an inflammatory disease with varied presentations thus leading to confusion whether asymptomatic individuals with suspected diagnosis of sarcoidosis should be investigated further. The clinical presentation of sarcoidosis varies from complicated and severe to uncomplicated and mild to asymptomatic sarcoidosis. A substantial percentage of sarcoidosis-affected individuals may never manifest clinical disease and upto 30% have spontaneous remission [1,2]. Diagnosis of asymptomatic presentations in sarcoidosis remains a challenge as it can influence prognosis. The presentation of sarcoidosis depends on epidemiological factors such as age, sex, and race, the duration of the disease and the sites of involvement. Overall, sarcoidosis is mostly revealed in the following circumstances: (i) respiratory symptoms, firstly persistent dry cough in around 30% cases, (ii) extra-thoracic localizations, mainly peripheral lymph nodes, eyes or skin, (iii) constitutional symptoms such as fatigue (27%), weight loss (28%), fever (10-17%) or night sweats and (iv) erythema nodosum (3-44%) [3,4,5]. Constitutional symptoms, particularly asthenia, are often present and can be a disabling problem . Finally, an incidental discovery of sarcoidosis in asymptomatic patients with chest X-ray aberrations is also not uncommon (8-60%) .
A 57-year-old non-insulin dependent diabetic male was referred to general surgical clinic from urologist where he was being treated for benign prostatic hypertrophy. Urologist incidentally discovered bilateral inguinal lymph nodes and sent him to the surgeon for further assessment. On examination, there were painless multiple bilateral inguinal swellings of size about 4×3 cm without any skin changes, erythema or tenderness. Axillary and cervical lymph nodes were not palpable. No significant findings were noted on abdominal, anal, genital and lower limb examination. Routine blood investigations revealed hemoglobin 10.5 g/dL (13-15), total leukocyte count 4600 cells/µL (4000-11000), platelet counts 330000 cells/µL, an erythrocyte sedimentation rate of 47 mm/hour (0-22), and C-reactive protein level of 4.8 mg/dL (<3 mg/dL). Ultrasound of abdomen revealed bilateral multiple pelvic lymphadenopathies, the largest on right side measuring 4×3 cm, and about 3.2×3 cm on left side. Ultrasound also showed bilateral multiple matted inguinal lymph nodes with largest lymph node about 4.2×2 cm. A computed tomography (CT) scan of the chest, abdomen, and pelvis revealed bilateral deep pelvic and inguinal bulky adenopathy, with 6×3 cm both pelvic sidewall mass, multiple enlarged bilateral inguinal lymph nodes measuring 4 cm. No abnormalities were noted in chest or abdomen. Excisional biopsy left inguinal lymph node was taken. The macroscopic finding showed, single large lymph node, 4.5×3×1.5 cm partly bisected, the cut surfaces showing white homogeneous areas [Fig.1a,1b]. Microscopy showed the destruction of lymphoid architecture by multiple caseating granulomas with a presence of multinucleated giant cells with the area of calcification (Shaumann bodies). The finding of chronic granulomatous inflammation was consistent with sarcoidosis [Fig.2a,2b]. The patient was treated with prednisolone tablets 40 mg daily for two weeks followed by 20 mg daily after four months. Multiple ultrasounds of his abdomen and inguinal region showed decrease in lymph nodes size. A repeated CT scan of his chest, abdomen, and pelvis 5 months after his initial diagnosis suggested satisfactory progress of sarcoidosis.
Sarcoidosis is the ubiquitous disease of unknown etiology, seen worldwide with a multisystem involvement . Early diagnosis is the key to prevent the potentially damaging effects of sarcoidosis. There is no laboratory test that will diagnose sarcoidosis for certain. Sarcoidosis is diagnostic dilemma due to an absence of precise consistent case definition, variability in clinical presentation and lack of confirmatory diagnostic tests.
Many people with sarcoidosis may not require any treatment, and self-resolution of sarcoidosis might occur after several years without causing serious complications. The diagnosis of sarcoidosis is established on the basis of compatible clinical and radiologic findings, supported by histologic evidence in one or more organs of non-caseating epithelioid-cell granulomas. Isolated peripheral lymphadenopathy is the uncommon presentation, particularly involving the cervical, axillary, epitrochlear, and inguinal nodes . Important differential diagnoses of granulomatous disease like Crohn’s disease, lymphoma, and vacuities should be excluded. In our case, inguinal lymph node biopsy showed caseating granuloma. The appropriate therapy for sarcoidosis has not yet been well defined for all patients [9,10,11]. Between 30 and 70% of patients never require therapy. In the other cases, a treatment, often corticosteroids, is necessary, either at the onset of the disease or during follow-up because of various consequences.
Sarcoidosis should be considered as a part of differential diagnosis in asymptomatic inguinal lymphadenopathy.
Contributors: SMMA wrote the manuscript, did literature search, will act as guarantor and approved final version of the manuscript.
Funding: None; Competing interests: None stated.
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